We further expected that the loss of current would be predominantly expressed in directly injured L5 neurons as compared with L4 neurons. 9,10We hypothesized that I Caloss is a generalized effect of painful sensory neuron injury and would be found after SNL as well as after chronic constriction injury. Because the relative roles of axotomized and neighboring intact neurons are unresolved, 8we compared neurons from the ligated L5 DRG and the adjacent L4 DRG.
5–7This model thus provides the opportunity to separately test the roles of neurons affected by these different pathogenic processes. The spinal nerve ligation (SNL) model of neuropathic pain 4segregates the somata of axotomized L5 neurons from the adjacent L4 neurons that share the sciatic nerve, where intact L4 axons are exposed to inflammatory mediators induced by the degeneration of distal segments of L5 neurons. These findings imply that decreased I Camay contribute to aberrant sensory processing, but it is not known whether I Caloss is solely a direct effect of axotomy or also an indirect effect of injury on adjacent, intact neurons. To exit the full screen mode, press F11 again.We have reported that chronic constriction injury 3of the sciatic nerve reduces calcium currents (I Ca) in somata of primary afferent neurons in the dorsal root ganglia (DRG) proximal to the injury. To view the text editor in full screen mode, press F11. Place the cursor anywhere in the text editor and press CTRL+V to insert the copied text from the clipboard. Select the desired text and press CTRL+C to copy it in the clipboard. Place the cursor anywhere in the text editor and press CTRL+A. To perform a function on all the content in the text editor, you need to select it all. You can use Redo command only after Undo command. You can reverse more than one action that has been undone. To reverse your last action, press CTRL+Z.
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